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While it is generally accepted that opioid withdrawal is not fatal, iatrogenic precipitated withdrawal may be much more severe resulting in clinically significant autonomic hyperactivity with consequences such as pulmonary edema and make patients more reticent to continue with future medication for opioid use disorder

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Immortalized BMDMs were generated using a CRE-J2 retroviral infection method 64

In recent years, there have been intensive studies demonstrating the protective effects of natural products against APAP-induced hepatotoxicity, providing considerable drug candidates for AILI