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Some patients start with weekly injections for 46 weeks, then transition to every 24 weeks for maintenance

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Splitting the weekly dose into two half-doses doesn't help, it just spikes side effects on each split, no smoother on either

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"It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycaemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brain's reward system." Meanwhile, a separate study has investigated unplanned pregnancies amongst individuals using GLP-1 receptor agonists during the early stages of pregnancy