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Study 3: Combination With Diet Independent work showed that NNMT inhibition plus a lean/low-fat diet accelerated weight and fat loss beyond diet alone, improved the lean-mass-to-body-weight ratio, and ameliorated obesity-linked liver pathologies

doi: 10.3390/jcm13082176

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However, with the site tutorial and some reinforcing from YouTube, it was painless and very easy

Good hygiene, a fresh single-use needle and safe disposal remove most of that risk