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This is commonly used in specialist obesity practice and generally safe when supervised by an experienced prescriber, though anything above 0.25 mg is technically off-label

A prefilled syringe/pen has been designed to safely store certain medications and maintain efficacy

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He reported fatigue, shortness of breath, paroxysmal nocturnal dyspnea, and bilateral leg swelling [New York Heart Association (NYHA) Class III]

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Kosiborod MN, Verma S, Borlaug BA, Butler J, Davies MJ, Jon Jensen T, et al