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Imaging studies revealed diminished activation in brain regions such as the insula, putamen, and orbitofrontal cortex when exposed to high-calorie food cues, suggesting that GLP1-S reshapes both physiological hunger responses and the motivational aspects of eating

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Clinical Evidence on GLP-1 and Corticosteroid Co-Administration Limited prospective clinical trials directly study GLP-1 and corticosteroid interactions, but case reports and observational data highlight increased glucose variability and reduced weight loss during concurrent use

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While these agents are still under investigation, they underscore a fundamental shift: obesity pharmacotherapy is moving beyond single-hormone mimicry toward integrated, multi-system approaches that more closely mimic the bodys complex physiology of weight regulation.