In the Phase III ATTain-1 trial, Orforglipron achieved weight loss of around 1112%, though there was a notable discontinuation rate due to gastrointestinal side effects
GLP-1 is expected to have pleiotropic effects on the liver, and more research is needed to explore its mechanism
Same total weight lost, dramatically different body composition outcome
(5) Dysmorphic features, developmental delay, or endocrinopathies (e.g., central hypothyroidism, GH or ACTH deficiency) [107] and (6) Normal or accelerated linear growth (suggesting genetic rather than hypothalamic etiology, especially in MC4R mutated-patients)
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