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The emergence of dysesthesia as a notable side effect is unique to retatrutide in this comparison

Peer review Peer review information Nature Metabolism thanks Hamlet Gasoyan, Jason Halford and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

No, not for adults 21 and older as of January 1, 2026

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The major part of the flux is carried by the low affinity transporter, which has sigmoidal kinetics with a V max in the range 9001400 M/hr, a K m of approximately 3000 M, and a Hill coefficient of approximately 3 [3436]

This is especially true if the peptides initiated a deep parasympathetic (rest-and-repair) response