Nat Med 23(7):850858

[10] Anterior pituitary In the anterior pituitary gland, the effects of somatostatin are: Inhibit the release of growth hormone (GH) [11] (thus opposing the effects of growth hormonereleasing hormone (GHRH)) Inhibit the release of thyroid-stimulating hormone (TSH) [12] Inhibit adenylyl cyclase in parietal cells Inhibits the release of prolactin (PRL) Gastrointestinal system Somatostatin is homologous with cortistatin (see somatostatin family) and suppresses the release of gastrointestinal hormones Decreases the rate of gastric emptying, and reduces smooth muscle contractions and blood flow within the intestine [11] Suppresses the release of pancreatic hormones Suppresses the exocrine secretory action of the pancreas Synthetic substitutes Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone, and has a much longer half-life (about 90 minutes, compared to 23 minutes for somatostatin)

Preventing Aging (Anti-Aging) Concern about ageing affects all people
10.1161/CIRCRESAHA.110.223818 31 SharmaV.DhillonP.ParsonsH.AllardM
Mechanism of Action Sermorelin binds to GHRH receptors on anterior pituitary somatotroph cells, activating a cyclic AMP (cAMP) signaling cascade that stimulates GH gene transcription, GH synthesis, and GH release
Due to a limited number of studies and incomplete information about drug dosages, we could not determine specific dosages and categorize them