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This is often triggered by stress, medication, or health issues, and in rare cases, an overuse of glutathione supplements

And when broken down by lean mass vs fat mass loss by DEXA scan it was similar to semaglutide 70% fat, 30% lean, which is also in line with bariatric surgery

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The activation initiates autophosphorylation at residues Y1349 and Y1356, leading to the formation of docking points for various adaptor molecules (such as GAB1, GRB2, SHC, CRK, PI3K, PLC1, SHP2, and STAT3), which facilitate the coordination of subsequent signaling [3, 15, 20]

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PMC 3517182