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The KELCH domain of the Keap1 homodimer binds to the DLG and ETGE motifs (ETGE acts as a hinge, and DLG acts as a latch) of the Neh2 domain of Nrf2 in the cytosol

Marks gained a scholarship to study medicine at the University of Oxford and then qualified as a doctor at St Thomas' Hospital in 1954

(2025) 10.1007/s12035-025-04832-6 [Epub ahead of print]

Future treatments may increasingly integrate GLP-1 with other therapies for a holistic approach

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Theoretically, patients could achieve more comprehensive metabolic improvementbetter insulin action, lower appetite, improved glucose handling, and favorable lipid changesby leveraging both pathways simultaneously