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Results and discussion Systemic GLP-1RA treatment reverses aging-associated transcriptomic changes in diverse mouse brain cell types We hypothesized that GLP-1RAs may be potent anti-aging therapeutics that impact diverse brain cell types

Multi-targets or single-molecule peptides with combined agonistic effects of GIPR, GLP-1R and GCGR have been widely explored

The plasma half-life of the intact peptide is approximately 30 minutes, significantly longer than unmodified tuftsin (2-3 minutes), confirming the stabilizing effect of the Pro-Gly-Pro extension