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Heme oxygenase 1 is required for mammalian iron reutilization

Int J Food Microbiol 136(1):7174 Wang X, Yu S, Wang CY, Wang Y, Liu HX, Cui Y, Zhang LD (2015) Advanced glycation end products induce oxidative stress and mitochondrial dysfunction in SH-SY5Y cells

This decline coincides with the decrease in the bodys regenerative capacities, which has motivated much of the research on this peptide

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Also, its growth hormone-stimulating properties make it unsafe for people with active cancer ,27 and its action on the pituitary gland means its unsuitable for people with a pituitary gland disorder