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The Clinical Pharmacology of GLP-1 Receptor Agonists GLP-1 receptor agonists mimic the incretin hormone glucagon-like peptide-1, which the gut releases after eating

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10.1016/j.fitote.2021.104915 12 EeckhautV.MachielsK.PerrierC

Although cortisol itself has anti-inflammatory effects, prolonged high levels of cortisol may induce glucocorticoid resistance, which in turn downregulates GC receptor-mediated transcriptional activity, diminishing its anti-inflammatory efficacy and exacerbating the inflammatory response (120)

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