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Hypothyroidism, polycystic ovary syndrome (PCOS), insulin resistance, and hormonal imbalances can all influence how your body stores and burns fat

Broadly, GLP-1RAs act to increase insulin secretion, decrease glucagon secretion, delay gastric emptying, and induce satiety [14, 19]

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The changing epidemiology of adult liver transplantation in the United States in 20132022: The dominance of metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease

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Conversely, individuals whose genetic makeup shows reduced GLP-1 responsiveness or elevated FTO-driven appetite drive may benefit significantly from tirzepatide's dual mechanism