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For example, I found several large meta analyses of studies where they grouped and assessed several prior randomized controlled trials and sort of lumped them together

It is well known that the biogenesis of bone is highly dynamic, with the process of bone resorption showing evident circadian rhythmicity (88)

[11] Other reported side effects include gastrointestinal disturbances (nausea, diarrhoea), skin reactions (including rare photosensitivity), and rarely, haematological abnormalities such as thrombocytopenia or agranulocytosis

No crash dieting or extreme restrictions

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