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Theoretical concerns are not proof of harm, but they identify areas off-target SAM effects, signalling-pathway impacts, and uncharacterised interactions that require study before any conclusion about human safety could be drawn

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These combined effects make them particularly valuable for studies focused on injury recovery, inflammation, and tissue stability

4 GHRH + GHRP synergyStudies on combined GHRH and GH-releasing peptide administration amplifying pulsatile GH secretion

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Thus, in this particular case of ischemic/reperfusion colitis, this may be a consolidation of the stimulatory and inhibitory effects of the NO-system to produce more effective healing (i.e., by promoting the interconnection of arcade vessels to bypass major obstructions) [194]