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Injectable drugs like Wegovy and Mounjaro are effective but less convenient than oral formulations and pharmaceutical companies are also pursuing the development of oral weight loss drugs

By the 1970s, one hormone was identified as an incretin candidate: Gastric Inhibitory Polypeptide (GIP) , discovered in 196970, which was found to stimulate insulin secretion (and renamed Glucose-Dependent Insulinotropic Polypeptide ) ( [30] )

A subsequent analysis of SELECT trial data presented at the 2025 European Congress on Obesity found that the heart benefits appeared within just a few weeks of starting the medication and were not entirely explained by weight loss alone

Injecting denatured peptide produces no melanogenesis and wastes the dose entirely

Marchi et al., 2022

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