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Logistic regression analysis revealed that the relationship between SaO 2 values and altitude could be used to predict AMS sensitivity, with their established model accurately predicting AMS susceptibility in 86% of participants

While hyperinsulinemia increases TC malignancy, metformin, an oral hypoglycemic drug, is verified to impede glycolysis and promote TCA cycle via downregulating LDHA and PKM2 and enhancing IDH1 expression [265, 266]

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Simply put, it helps you feel fuller for longer, reducing cravings and potentially leading to decreased calorie intake

Additionally, it lowered pro-inflammatory cytokines like TNF- and IL-1, showing anti-inflammatory actions

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