Role of reactive oxygen intermediates and cognate redox signalling in disease resistance
All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells
It has been reported that the GSTP1 Val105 not only has a significantly lower affinity for glutathione, but also is more sensitive to inhibition by Hg species 38
In addition, other cytotoxic or lytic peptides, such as defensin 1 (ACYCRIPACIAGERRYGTCIYQGRLWAFCC), cecropin B (KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL), magainins (GIGKFLHSAKKFGKAFVGEIMSNS), and dermaseptin (ALWKEVLKNAGKAALNEINNLVG), can increase membrane permeability and promote cell death 60,61
Glutathione plays a critical role in regulating immune cell activityincluding the production and function of white blood cells
increases the binding of PAHs to their receptors