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Castillo, P

Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

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Additionally, pharmaceutical companies can use contract manufacturing, which is also called third-party manufacturing, to delegate their entire production operations to established manufacturers who operate state-of-the-art production facilities and hold necessary industry certifications and employ qualified personnel