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Data availability The dataset analyzed in this study is available from the corresponding author on reasonable request

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RA is pathologically manifested as immune cell infiltration, hyperplasia of the synovial lining, pannus formation, and destruction of articular cartilage and bone ( To date, a large number of clinical trials have been performed by scientists and clinicians for testing different types of agents in RA treatment

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The present systematic review, being the first to summarize the in vitro potential of short peptides to be used with cells and tissues of the oral cavity, found that short peptides can play an important role in oral health, acting on several fronts

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doi:10.3389/fphar.2025.1551843 Wang X, Liu B, Xu Q, et al

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