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However, an imbalance favoring excessive ROS production can lead to oxidative damage, negatively affecting male fertility potential and reproductive outcomes (7, 8)

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Anal Biochem 106 : 5562 Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I 2006 Cigarette smoke induces proinflammatory cytokine release by activation of nf-kappab and posttranslational modifications of histone deacetylase in macrophages