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In recent years, a class of diabetes and weight loss medications called Glucacon-Like Peptide-1 Receptor Agonists (often referred to as GLP-1s and semaglutide) have transformed the landscape of weight management and type 2 diabetes care

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The Journal of Clinical Endocrinology and Metabolism

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[1] DPP-4 Resistance and Metabolic Clearance Unmodified GLP-1 is rapidly cleaved at position 2 (AlaPro) by dipeptidyl peptidase-4 (DPP-4), giving a native half-life of ~2 minutes