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The IGF-1R promoter exhibits a high basal transcriptional activity, and is under physiological control of nutritional factors (Olchovsky et al, 1993), hormonal stimulation (Clarke et al, 1997) and the developmental stage (Bondy et al, 1992)

Chemical inhibition of NOS or nNOS knockout in mice muscle abolished such effects while NO donors raise cGMP level and glucose uptake [71]

Jung YY, Ha IJ, Lee M, Ahn KS

Ngi tp luyn th thao thng xuyn c th cn t 1.2 n 2.0g protein/kg trng lng c th mi ngy

GST overexpression and polymorphisms are seen in several cancers as well as other diseases, and have been implicated in resistance to chemotherapy 2,3

99 Folate also enhances regeneration of BH 4 from inactive BH 2 by stimulating dihydrofolate reductase and it chemically stabilizes BH 4