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Each trial involved placing the animal on a rotarod revolving at 5 rpm/min, then accelerating at 0.6 rpm/min

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Observations indicate that MT-1 may modulate the balance of matrix metalloproteinases (MMPs) and their inhibitors, as well as reduce the expression of genes associated with fibrogenesis

Dual GLP-1/glucagon receptor agonists, including mazdutide, integrate appetite suppression with increased energy expenditure and fat oxidation, while triple GLP-1/GIP/glucagon agonists, such as retatrutide, further augment these mechanisms through multi-pathway receptor engagement

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