That is meaningful evidence that the ingredient can work in the right formulation
B12 (hydroxocobalamin is listed as an essential medicine by WHO (see page 19 here) but it seems this is not understood by many GPs
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It works by inhibiting the NNMT enzyme, which is associated with fat storage, insulin resistance, and reduced cellular energy
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice
It is not intended to diagnose, treat, cure, or prevent disease, and it should not replace care from your physician