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Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Verma S, Jensen TJ, Einfeldt MN, Liisberg K, et al

225 Furthermore, in CRC cells, lactylation enhances cell differentiation and metastasis via the activation of the PI3K/AKT signaling pathway and Snail-mediated EMT, driven by PCSK9

10.1111/j.1471-4159.2007.05174.x 17

Gibson, Manuscript collections: the archival collections at the Center for Dubuque History

Additionally, it acts through the TLR4/HDAC/NF-B signaling pathway by downregulating TLR4, MyD88, and TRAF6 expression, inhibiting NF-B p65 phosphorylation, and blocking HDAC1 and HDAC2 activity