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The method of synthesis according to claim 1, characterized in that: the reagent used for controlling the reaction pH value in the step (1) is a solution consisting of alkali, water and an organic solvent, wherein the alkali is selected from organic alkali or inorganic alkali, the organic alkali is selected from any one of triethylamine, N-diisopropylethylamine, pyridine, piperidine and aniline, and the inorganic alkali is selected from any one of alkali metal hydroxide and alkali metal carbonate, such as sodium hydroxide, potassium hydroxide, sodium hydrogen phosphate and potassium hydrogen phosphate

We did not observe a difference between Pomc.GLU-5 and Agrp.GABA-4 neurons and all other hypothalamic neurons in these signalling pathways in mice treated with acyl-GIP or MAR709 (Fig

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