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Due to the side effects linked with these therapeutic agents, including hepatotoxicity, cardiovascular complications, and gastrointestinal lesions, 3050% of patients do not respond effectively to the standard therapies, thereby decreasing the inclusive benefits of the treatment on a long-term basis

It is a 15-amino acid peptide sequence derived from a naturally occurring protein found in human gastric juice

Circulation 116 (8), 944953

while serum values of B12 seem to rise, none of the B12 is available for the body to use

In this model, treatment with vitamin D attenuated accumulation of TH17 and TH2 cells and development of airway hyperresponsiveness