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Some people may feel benefits for several weeks, while others may require ongoing support depending on the reason for low B12

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This is the case of some DHAR isoforms which have CPFC active sites

Whilst early clinical studies of the NPY antagonist velneperit were encouraging with a reported additional 2.8 kg weight loss compared with placebo over 16 weeks [95], subsequent phase IIb studies were disappointing and studies were discontinued

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