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doi: 10.1152/ajprenal.00228.2016

Randomized participants follow an 8-week dose escalation regimen (3 mg [weeks 04], 7 mg [weeks 48], and 14 mg [weeks 8156])

The encircled active site, unique to NS5B, is contained within the palm structure of the protein

For all the aforementioned experiments, the Dual-Luciferase Reporter Assay System (Promega Corporation) was used to measure luciferase activity strictly according to the manufacturers instructions

It helps relieve or prevent fatigue and may have acted in the anti-inflammatory process by reducing histamine release

When adverse effects occur, they are typically mild and may include: Nausea or stomach upset Diarrhea or loose stools (particularly at higher doses) Dizziness Headache Fatigue These effects are usually dose-dependent and resolve with dosage adjustment