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A total of 34% of recipients of a 2 mg dose had gastrointestinal symptoms compared with 30.8% of those receiving a 1 mg dose
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This is called first-pass metabolism and it can significantly reduce the effective dose
Interindividual variation in biotransformation and bioavailability may also affect the efficacy of tea as a cancer preventive agent
Smith SB, Huang W, Chancy C, Ganapathy V
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