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Hepatology 68(1):234247

In pancreatic -cells, uric acid triggers ERK activation, resulting in reduced cell viability, apoptosis, and the production of reactive oxygen species

Timeline for resolution Based on available data, the timeline for resolution varies by management strategy

For example, NRF2 inhibition in cancer-bearing hosts, especially in myeloid cell lineage, promotes metastatic colonization of cancer cells in the lung by augmenting the activity of myeloid derived suppressor cells (Satoh et al

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According to Hayward et al