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Diabetes Care 44(3):765773 Kim WJ, Lee SJ, Lee E, Lee EY, Han K (2022) Risk of incident dementia according to glycemic status and comorbidities of hyperglycemia: a nationwide population-based cohort study

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The Arg3 change reduces its binding to IGF-binding proteins, so it stays active in the bloodstream longer around 20 to 30 hours compared to just minutes for standard IGF-1