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Such studies have shown that antibiotic administration might increase the effectiveness of L-DOPA therapy, indicating that gut microorganisms affect metabolism and the effectiveness of the drug (Hashim et al., 2014)

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EBioMedicine 20: 230-239

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To interrogate whether melatonin could restrain ILC2 effector function we employed an adoptive transfer model, whereby activated ILC2s were isolated from Rag2 -/- mice, cultured for 24h in the presence or absence of melatonin, and then adoptively transferred the ILC2s into Rag2 -/- GC -/- mice utilizing established protocol as described by our group previously (48, 49) ( Figure 4A )