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Except for orforglipron, incretin-based drugs appeared to increase HDL-cholesterol up to approximately 13% with pooled tirzepatide doses

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10.1016/j.biopha.2021.111585 239 XiaY.LiuS.LiC.AiZ.ShenW.RenW.et al (2020)

Dosage modifications, typically ranging from 200 to 500 mcg per day, can be made to optimize growth hormone stimulation while minimizing side effects like water retention or injection site irritation