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Of significant concern is whether or not impurities that make the peptide appear more foreign (by changing the tolerogenic epitope) might impact the immunogenicity of the drug product

Clinical trials show that Tirzepatide produces a higher average weight loss than Semaglutide, largely because it activates two hormone pathways rather than one

Injections can also cause injection-site reactions

Personalized Treatment Planning with Genetic Insights Individual response to GLP-1 medications varies widely based on genetics

Almeida, A., Delgado-Esteban, M., Bolanos, J

References de Baat A, Trinh B, Ellingsgaard H, Donath MY