The conformational changes in IGF-IR create docking sites for its substrates, such as Shc and InsR substrates (IRS), which relay the signaling to downstream effectors including PI3K, MAPK, and STAT3

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doi: 10.3389/fmolb.2023.1170181 Received 20 February 2023 Accepted 28 March 2023 Published 07 April 2023 Volume 10 - 2023 Edited by Catalina Dirney Alba Soto, University of Buenos Aires, Argentina Reviewed by Jacek Mokrosinski, Novo Nordisk Research Center Indianapolis, United States Brian Hudson, University of Glasgow, United Kingdom Updates Copyright 2023 Austin and Tomas
This suggests that higher tirzepatide doses may slightly increase fatigue risk, although the rates remain relatively low
So, ongoing clinical studies and real-world data collection need to provide valuable insights into the safety and efficacy of combining Tirzepatide and alcohol