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This is especially true as we age or when we are dealing with high levels of environmental stress, which can deplete our natural stores faster than we can replace them

One pathway (GLP-1) handles the incretin response, while the other pathway (amylin) handles the satiety response

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The most frequently reported adverse effects in clinical trials were gastrointestinal in nature, reflecting tirzepatide's mechanism of action as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

doi: 10.1111/dom.13340 44 WeinstockRSGuerciBUmpierrezGNauckMASkrivanekZMilicevicZ

Some cases have been severe enough to require hospital treatment