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Similar content being viewed by others Introduction Maintenance of mitochondrial function and adaptation to changes in nutritional state is vital for the preservation of pancreatic -cell regulated secretion of insulin 1 , the main hormone in charge of lowering blood glucose concentrations, with disruptions in this process underlying the development and/or progression of type 2 diabetes (T2D) 1,2 an uncontrolled pandemic affecting 500 million people worldwide, and causing 1.5 million deaths per year 3
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Where GLP-1 primarily activates hypothalamic neurons involved in energy balance, amylin targets hindbrain circuits that regulate meal-specific satiety and food reward
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