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this effect appears to be more pronounced in females owing to sex-specific regulation of adipogenesis

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9 The UTSMC study protocol reduced insulin doses by 20% if the A1c was less than or equal to 8%

7 Changes in the brain cytoplasmic [NAD + ]/[NADH] and [NADPH]/[NADP + ] with aging are rodent strain and species specific Through measuring the metabolome of young and aged C57BL/6J mouse brains, the lactate/pyruvate, a proxy for the cytoplasmic [NADH]/[NAD + ], was found to increase by 34%52% with aging, indicating a cytoplasmic reductive shift (Dong and Brewer, 2019), opposite to the oxidation of mitochondrial [NADH] that was found to occur in aged neurons (Dong et al., 2019a)

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