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While muscle loss is standard with any diet or weight-loss regimen, loss of muscle on GLP-1s can be more dramatic, Ahmed says, causing what's been dubbed "Ozempic face," a bonier, looser-skinned look, where the muscle loss is particularly noticeable

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The clinical researchers who are most optimistic about GLP-1 drugs for chronic pain, including Dr Ilene Ruhoy, are using considerably lower doses than the obesity trials, sometimes 5 to 10 times lower, around 0.25 to 0.5mg per week rather than the 2.4mg used in weight loss trials