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Flensted-Jensen, M

D., and Tor, Y

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The agency has separately received adverse event reports that may relate to patients being prescribed compounded semaglutide or tirzepatide in doses beyond what is in the approved labeling more product per dose, more frequent dosing, or faster titration with reported symptoms including nausea, vomiting, diarrhoea, abdominal pain and constipation, some serious enough that patients sought medical attention

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Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice