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Mounjaro activates both GIP and GLP-1 receptors simultaneously, whilst exendin-4-based therapies like exenatide act solely on GLP-1 receptors

These medications have shown promising results in helping patients improve glycemic control and achieve weight loss, making them a popular treatment option ( 5 9 )

Notably, GLP-1 RA use did not lead to increased rates of GERD complications, esophageal cancer, or a greater need for diagnostic or surgical interventions

The result is meaningful weight loss that often benefits from a surgical finish

Why it's used: Highly processed, low in nutrients, and may contribute to weight gain and other health problems

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice