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Frontiers in Medicine, 10

The spectrophotometric absorbance of the samples was read using a ELISA microplate reader at 450 nm with 630 nm as a reference wavelength

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The mechanisms promoting drug resistance include the following: first, at the pharmacokinetic level, the overactivation of drug efflux pumps is mediated by ATP-binding cassette transporters (ABC transporters)

Standard Therapeutic Cycle (12 Weeks): Clinical trials frequently employed 12-week protocols, which provide sufficient duration for measurable metabolic changes while establishing safety through comprehensive monitoring

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