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Nasally administered drugs can across the epithelium in the lateral respiratory region and then to the pons through the trigeminal nerve (Thorne et al., 2004

We used a modified Cochrane risk of bias tool to assess the risk of bias, used GRADE to assess the certainty of evidence, and used the Credibility of Effect Modification Analyses (ICEMAN) tool to assess the credibility of any apparent subgroup effect

Multi-agonist therapies combining GLP-1 with GIP or glucagon may amplify these benefits by improving fat metabolism and reducing cardiovascular risk even further

Potential Side Effects And Unknowns Reported concerns with weight loss patches include skin irritation, contact dermatitis, allergic reactions to adhesives or botanical ingredients, and gastrointestinal discomfort related to absorbed compounds

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