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These findings highlight the synergistic effects of genetic and environmental factors, which can guide targeted clinical approaches

In AD, NF-B activation is linked to -amyloid plaque-induced microglial stimulation [445], while in PD, -synuclein aggregates act as DAMPs that activate TLR2 [446]

This dual action mitigates oxidative stress in both peripheral and brain tissues, thereby inhibiting further deterioration of cognitive deficits-associated behaviors (134)

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