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Targeting autophagy for AILI treatment Autophagy is a tightly regulated cellular process that renew cell through removing unwanted cytoplasmic contents, including misfolded or aggregated proteins, accumulated lipids, excessive or damaged organelles and harmful pathogens, via lysosomal degradation [80]
Furthermore, Humanin's ability to attenuate inflammation and promote tissue repair opens new avenues for therapeutic interventions
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Previous studies have shown that factors such as BMI and waist-to-height ratio (WHtR) are much more affected by an individuals lifestyle and genetic predisposition than energy intake or possible greenhouse gas emissions 9
However, targeting metabolic pathways may lead to unintended toxicity in normal cells that share similar metabolic dependencies with tumor cells
