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Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system

Notably, in mice studies, GH secretagogue receptor suppression in adipose tissues protects against obesity and insulin resistance (97), whereas IGF-I increases skeletal muscle insulin sensitivity (98)

doi: 10.1002/biof.1385

Labad J, Stojanovic-Perez A, Montalvo I, Sole M, Cabezas A, Ortega L, Moreno I, Vilella E, Martorell L, Reynolds RM, Gutierrez-Zotes A

However, the involvement of vagal afferent nerves in mediating the effects of ghrelin remains a contentious topic (69) (Figure 2)