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Gene expression on BDNF and SK-3 was quantified using real-time PCR, revealing that VPA reduced the expression BDNF, which plays a crucial role in synaptic plasticity and neuronal survival, and increased GSK-3, which is involved in neurodevelopment and neuroinflammation whereas crocin dose-dependently normalized both markers (Hosseini et al., 2025)

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Additionally, it was demonstrated that the long-acting triagonist protected against Parkinson disease in mice by attenuating microglial activation and inflammation in the specific brain regions [31]

Tapering from 15 mg If you are currently on the maximum 15 mg dose , here is a suggested schedule

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